Paolo Calabresi (Italy) Basic Science Committee
  Paolo Calabresi is Full Professor of Neurology and Chief of the Clinical Neurology Section at the University of Perugia, Italy. He is the Director of the Experimental Neurology Laboratories at the University of Perugia (Italy) and Roma IRCCS Fondazione S. Lucia (Italy). He currently coordinates a clinical and preclinical research group composed of approximately forty-five people (with different levels of seniority). Prof. Calabresi is also the Scientific Coordinator of the Neuroscience Ph.D. program of the School of Neurology of the University of Perugia.

In the last two decades, Prof. Calabresi’s research has investigated the synaptic communication between the cerebral cortex and the basal ganglia, focussing on corticostriatal synapses and their activity-dependent plasticity. In particular, Prof. Calabresi’s group has extensively investigated how corticostriatal communication depends on the activation of dopamine receptors and how it is affected by pathological conditions such as Parkinson’s disease. The research group coordinated by Prof. Calabresi has been the first, in 1992, to describe a novel form of striatal synaptic plasticity, named long-term-depression (LTD). This vital feature of corticostriatal synapses has then been fully characterised by Prof Calabresi’s group from a pharmacological and electrophysiological point of view. In 2003, Prof. Calabresi has been the first to hypothesize a correlation between dysfunction of corticostriatal synaptic plasticity and the clinical phenotype of both Parkinson’s disease and the complications of its long-term pharmacological treatment. Thanks to the continuous effort to translate electrophysiological results into the clinical field, Prof. Calabresi’s results have, over the years, had a strong impact in the medical field. Furthermore, in the last few years he has established new interdisciplinary approaches by applying the study of striatal plasticity to different pathologic conditions such as brain ischemia, Huntington’s disease, epilepsy and drug addiction.

The international leadership of Prof. Calabresi in the field of basal ganglia physiology is proved by more than 350 scientific articles, mainly published on high impact peer-reviewed international scientific journals, such as Nature Neuroscience, Lancet Neurology, Brain, Journal of Neuroscience, Neuron and Nature. The impact of these studies is reflected by Prof. Calabresi (h-index 85).
Prof. Calabresi is a member of the Editorial Boards of The Lancet Neurology; he has been member of the editorial board of The Journal of Neuroscience and Movement Disorders; he has been an invited speaker at several international meetings in the field of synaptic dysfunctions and movement disorders. For about six years, Prof. Calabresi has been the representative of the Italian National Research Centre (CNR) at the International Brain Research Organization (IBRO) and he has been appointed as an invited member of the American Neurological Association. His research group has consistently secured numerous European and international grants to support his research.

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